Vol. 1, Issue 3 (2016)
Taxomyces andreanae: A source of anticancer drug
Author(s): Ved Prakash, Shelly Rana, Anand Sagar
Abstract: Plant endophytic fungi spend the whole or partrnof their life-cycle colonizing inter or intra-cellularly inside the healthyrntissues of the host plants without causing any apparent harm to the host plant.rnTaxomyces andreanae, a hyphomycetous endophytic fungus is foundrnsymbiotically associated with its host plant, Taxus brevifolia andrnproduces anticancer bioactive compound Taxol (paclitaxel). Biosynthesis ofrnTaxol in this endophytic fungus starts with the cyclization of terpene,rngeranylgeranyl diphosphate and involves enzymes from different classes whichrnare located in different cellular compartments. Taxol, a highly-oxygenated diterpenoid natural product is therapeuticrnbecause acts as a mitotic spindle poison which inhibits uncontrolled cancerousrngrowths. The aim of present study is to review the research status onrnTaxol-producing fungal endophyte, Taxomyces andreanae and the ongoingrnefforts to develop heterologous Taxol biosynthesis.