Vol. 1, Issue 7 (2016)
Hepatoprotective activity of Averrhoa carambola against paracetamol induced liver toxicity in mice
Author(s): Ganesan Ramesh kumar, Palpandian Prema
Abstract: Liver is considered to be the master gland of the body as it is involved in various biological functions such as growth, immunity, energy supply, detoxification, reproduction etc. Therefore, maintenance of a healthy liver for normal functioning of human body is highly essential. Liver cells are damaged by various exogenous agents like microorganisms, chemotherapeutic agents and alcohol. The Indian traditional medical system suggests many plants for the treatment of liver ailments. A plenty of plant families are still unexplored for their bioactive potentials. The objective of the present study was to evaluate the hepatoprotective effect of methanolic extract of Averrhoa carambola on paracetamol-induced liver damaged Swiss albino mice. Administration of plant extract (200 mg/kg and 400 mg/kg) significantly reduced the effect of paracetamol-induced toxicity on the blood serum markers of liver damage such as Serum Glutamic Pyruvic Transaminase (SGPT), Serum Glutamic Oxaloacetic Transaminase (SGOT), Alkaline Phosphatase (ALP) and Bilirubin. This study, therefore, showed the potential of Averrhoa carambola extract to reduce the levels of serum marker enzymes which indicate the protection of liver cells against paracetamol induced liver damage.