Evaluation of prominent Isoflavonoids of Iris plant as futuristic cancer drug components
Sajad H Wani, Shabir Ahmad Lone, Mir Faisal Mustafa, Javid I Mir, Raies A Qadri, Qazi Parvaiz Hassan
Three important constituents of Iris plant - Iridin, Irigenin and Tectorigenin, belonging to the isoflavanoid class of compounds were evaluated for their effectiveness in modulating growth of epithelia cancer cell lines A549 and Caco-2 and their possible effect on signalling molecules affecting cancer progression-EGFR, AKT and K-Ras. While all the compounds were able to limit cancer growth in a dose dependent manner in both A549 and Caco-2 cells, Tectorigenin was most effective among them (IC50 (tectorigenin) = 7.15μM for A549 and 23.39μM for Caco-2). Iridin and Tectorigenin were also observed to cause a dose-dependent downregulation of KRAS expression in A549 cells supporting their anti-cancer capabilities. With future evaluation of these compound(s) in a highly specific co-culture model there is tremendous scope of these compounds in drug design and futuristic use.