Vol. 2, Issue 3 (2017)
Development and standardization of polyherbal formulation for the management of tuberculosis
Author(s): Khushboo Jethva, Dhara Bhatt, Sonal Patel, Maitreyi Zaveri
Abstract: Tuberculosis also called TB is currently a major health hazard due to drug-resistant forms of bacilli. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity and fewer side effects in combination with vaccines. To develop drugs from these new sources, additional work is required for preclinical and clinical results. Since ancient times, different plant part extracts have been used as traditional medicines against diseases including tuberculosis. This knowledge may be useful in developing future powerful drugs. The present study deals with the development of the polyhedral formulation comprising of the aqueous extracts of Oscimum sanctum, Alpinia galanga, Adhatoda vasica and Long pepper. The Preformulation parameters and parameters for finished product (hard gelatin capsule) include uniformity of weight, disintegration time, moisture content, pH, phytochemical estimation were performed. The anti-tuberculosis activity of the finished product was performed using Cup and Bore method on Mycobacterium smegmatis. The prepared finished product showed significant anti-tuberculosis activity against Mycobacterium smegmatis.