International Journal of Botany Studies

Authors
Prajapati CK, Reddy MN, Bhatt MH

Abstract
The present study was designed to evaluate anticancer activity of crude extract of Simarouba glauca in three cancer cell lines viz., K-562, MOLT-3 and KG-1. Different concentrations (2 to 64 μg/ml) of leaves extract were tested for cytotoxicity using MTT assay. Methanolic extract of Simarouba glauca leaves showed significant anticancer activity against MOLT-3 and K-562 as compare to KG-1 cell line. Concentration required for a 50% inhibition of viability (IC₅₀) was determined graphically. IC₅₀ values of Simarouba glauca methanolic leaf extract with respect to K-562, MOLT-3 and KG-1 were found to be 74.21, 69.69 and 131.1μg/ml respectively. The methanolic leaf extract of Simarouba glauca exhibit effective activity against leukemic cancer cell lines. Leaf of Simarouba glauca can be recommended for cancer treatment especially for leukemic cancers.