Evaluation of anticancer activity using leaf extract of Simarouba glauca on leukemic cancer cell lines
Prajapati CK, Reddy MN, Bhatt MH
The present study was designed to evaluate anticancer activity of crude extract of Simarouba glauca in three cancer cell lines viz., K-562, MOLT-3 and KG-1. Different concentrations (2 to 64 μg/ml) of leaves extract were tested for cytotoxicity using MTT assay. Methanolic extract of Simarouba glauca leaves showed significant anticancer activity against MOLT-3 and K-562 as compare to KG-1 cell line. Concentration required for a 50% inhibition of viability (IC50) was determined graphically. IC50 values of Simarouba glauca methanolic leaf extract with respect to K-562, MOLT-3 and KG-1 were found to be 74.21, 69.69 and 131.1μg/ml respectively. The methanolic leaf extract of Simarouba glauca exhibit effective activity against leukemic cancer cell lines. Leaf of Simarouba glauca can be recommended for cancer treatment especially for leukemic cancers.
Prajapati CK, Reddy MN, Bhatt MH. Evaluation of anticancer activity using leaf extract of Simarouba glauca on leukemic cancer cell lines. International Journal of Botany Studies, Volume 3, Issue 2, 2018, Pages 52-56