Vol. 5, Issue 6 (2020)
Anti-cancer potential of siddha herbo mineral formulation parangi rasayanam against hela cell lines: A in vitro study
Author(s): Kaaruniya G, Sivakkumar S, Visweswaran S, Mariappan A, Meena Kumari R
Abstract: Siddha system of medicine is a system blended with Tamil culture. In Siddha system, there are many higher order herbo mineral/ herbo metallic formulations which are exclusively indicated for the management of Non – communicable diseases like Diabetes, Hypertension, Cancer, etc.., Among this, Cancer is considered to be one of the leading cause of morbidity and mortality worldwide with a mortality rate of 9.6 million in 2018. Of which, Cervical cancer is found to be one of the common types of cancer in women representing 6.6% of all female cancers. Though many modern therapies like surgery, radiation therapy, chemotherapy and targeted therapy, palliative care, stem cell therapy, adjuvant therapy are available they contain certain risks and side effects. Hence, the use of herbal medicines in cancer treatment has received increasing attention because of their easy availability, low cost and minimal side effects. Their therapeutic efficacy is attributed due to their various phyto-metabolic contents with multiple biological activities. Parangi Rasayanam (PRM) is one such herbo mineral siddha formulation which is indicated for Penkuri putru (Cervical cancer); Aankuri putru (Penile cancer); Megam (Veneral diseases); Parangipun (Veneral sore); Kandamalai (Nodular swelling of neck) and Kiranthi (Nodules). Hence, the study is aimed to evaluate the anti-cancer effect of Parangi Rasayanam in HeLa Cell Lines using MTT Assay. The result of the study reveals that it has 49.53 % of cell viability and 50.47% of cell death at a concentration of 200 microgram/ml with IC50 value as 183.7. This anti-proliferation may be due to the presence of Kaempferol (Flavonoid) in Smilax china which inhibits cell multiplication through induction of G2/M phase growth arrest. Hence, this study concludes that Parangi Rasayanam possess anti-cancer potential and further efficacious pharmacological and clinical studies have to be conducted for the welfare of cancer patients in the management of cervical cancer.