The aim of the current study was to assess Acalypha indica methanolic leaf extract for its anti hemolytic activity, anti-bacterial activity and its various phytochemical constituents. The methanolic leaf extract of Acalypha indica shown to have reasonable anti hemolytic activity. The methanolic extract showed antihemolytic activity in the range from 27% to 54%. At varying concentration of plant extracts 20, 40, 60, 80 and 100 mg /ml the percent of inhibition of hemolysis recorded were 27%, 34%, 40%, 47%, 54% respectively. The methanolic leaf extract of Acalypha indica showed significant inhibitory effect on all of the five bacterial species such as Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Streptococcus mutans. The inhibition zones for S. aureus were 14 mm, 16 mm and 20 mm (including well 4 mm) at concentrations of 15 µl, 20 µl and 25 µl respectively. The inhibition zones P. aeruginosa were 14 mm, 14 mm and 16 mm, 10 mm, 11 mm and 20 mm for Streptococcus mutans. The zones for E. coli were 10 mm, 12 mm and 21 mm and 14 mm, 16 mm and 19 mm for Bacillus subtilis. The phytochemical investigation of methanolic extract of Acalypha indica leaves showed the presence of carbohydrates, flavanoids, alkaloids, phenols and saponins.