The objective of this research was to determine the antibacterial and antifungal activities of the five medicinal plants against Streptococcus pneumoniae. Aloe secundiflora was more effective followed by Vernonia brachycalyx, Terminalia brownii, Carissa edulis and Tithonia diversifolia. In the case of solvents, ethanol was the best then water, ethyl acetate and lastly hexane. The work envisaged by this research includes determination of the efficacies of the solvent extracts used in the treatment of bacterial and fungal diseases. Further separation of solvent extracts was done using column chromatography. Bioassay guided chromatography revealed the activity trends. Hence in this study, the antibacterial and antifungal activity of selected medicinal plants were tested against bacterial and fungal isolates.