The present study aims to assess medicinal plants in Jizan region comparing with total medicinal plants in Saudi Arabia Kingdom. The result revealed that there are 306 species present in the Kingdom with 11 endemic species on the other hand, there are 141 species in Jizan region which constitute about (46.08%) of total medicinal plants in the Kingdom with 5 endemic species with (45.45%). This study confirms on importance of medicinal plants protection because almost of them are rare or endangered species.