Aqueous and ethanolic extracts obtained from Thymbra spicata L. var. spicata L. have been investigated for their ability 35 hospital isolates of Methicillin-resistant Staphylococcus aureus (MRSA). Both aqueous and ethanolic extracts of the plant were effective on MRSA. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values of the ethanolic extract with greatest antibacterial activity were those of T. spicata var. spicata MIC 3.2-6.3 mg/mL and MBC 6.3-12.5 mg/mL, respectively.