The antimicrobial activity of Zingiber Officinale (Ginger) and Curcuma longa (Turmeric) tested with Agar Well Diffusion method. Four different bacterial strains (Streptococcus pneumonia, Streptococcus mutans, Pseudomonas aeruginosa and Streptococcus pyogenes) were used to test antimicrobial activity of Ginger and Turmeric. Zingiber Officinale (Ginger) and Curcuma longa (Turmeric) extracted in five different solvents viz. Methanol, Ethanol, Diethyl ether, Chloroform and Water. Extracts were directly applied against bacterial strains growth to reveal their antimicrobial activity. Methanolic extract showed maximum inhibitory effect against selected strains followed by Ethanol (for Ginger) and Diethyl-ether for (Turmeric) and vice versa. Chloroform depicted inhibitory effect at the second last position and Water extracts found to have least inhibitory potential. Among two species Turmeric made higher Zone of Inhibitions (ZI) than Ginger. There is another finding that there is present direct correlation with the concentration of extracts and ZI values. This study confirms the Folktales about these two plants that they have high antimicrobial activity and confirms their position as novel Plants among other Ethnobotanical species.