Plant extract of Nerium contains some secondary metabolites. Plant has the capacity of anticoagulant specific to scorpion venom at certain moderate concentration. Traditionally some plans are used on the treatment on snake bites and scorpion bites. The anticoagulation activity can be measured by incubation time with egg yolk at certain temperature. Plant leaf extract shows best anticoagulation activity. Scropion venom is belong to chlorotoxin. Nerium plant extract is used on the treatment on scorpion bite.