Medicinal uses of plants used by different people from Dharmapuri district of Tamil Nadu, based on survey is presented. A total of 163 species from 134 genera and belonging to 59 vascular plants are enumerated: the dominant families along with life forms are included. The list of prioritized medicinal plants by National Medicinal plant Board along with red listed and Highly Traded medicinal plants are also included. The threat faced by these plants are indicated along with the utilization.