Different parts of Ferronia elephantum corr. Is being used for various ailments by the local people in north Karnataka region. In the present work we collected leaves in and around Bijapur district in the month of January 2014, shade dried and crushed into raw powder. Continuous solvent extraction of the powdered leaves using soxhlet was carried out with hot methanol. The methanolic extract showed positive results for glycosides and alkaloids. The antimicrobial evaluation of methanolic extract using two gram positive, two gram negative bacteria and two fungi at different concentrations was carried in comparison with a standard drug by cup pate method.