As per API, official source of Indravaruni is Citrullus colocynthis Schard. Cucumis prophetarum Linn. and Trichosanthes palmata Roxb. are the other source plants of Indravaruni mentioned in classics as well as modern textbooks in the context of botany as well as its medicinally uses. Review shows the leaves of C. prophetarum used in biliousness, fever, purgative agent while the leaves of T. palmata are used in burns. The study is taken to fulfill the lacuna of these unexplored plants in the context of individual and comparative pharmacognosy aspects of leaf. The leaves of both the species are simple, petiolate, scabrous. T.S. of petiole shows epidermis, cortex, vascular system and ground tissue. T.S. of C. prophetarum midrib shows 3 vascular bundles while T. palmata possess 4 vascular bundles. Anomocytic stomata are present in both species. The common diagnostic powder characters are like multicellular covering trichome, cystoliths etc