Clove (Syzygium aromaticum) is naturally occurring spice used as a drug and a preservative due to its antimicrobial and antioxidant properties. Clove is a native of Indonesia but is also cultivated in many coastal areas at higher altitudes around the world. Health benefits of clove have been proved from centuries in treatment of many ailments and disease. Clove also shows antimicrobial, antiviral, anti-inflammatory, hepatoprotective, anti-stress, antinoceptive, anesthetic activities. Larvicidal activity of clove in dengue is a new application. Commercially, clove has been used for volatile oil extraction in formulating medicinal, food and cosmetic products. Clove oil comprises of many phytoconstituents, eugenol being an important one of the phenolic compounds. In respect to the points mentioned, this report is one of its kind as an attempt has been made to compile knowledgeable data of clove together in this article. Pharmacological activities, botanical description, phytochemistry, toxicity studies and uses of clove have been discussed.