This study was done to examine the anticancer activity of hydroalcoholic extract from the leaves of Madhuca longifolia ieMLHA against Breast Carcinoma in mice. The activity was evaluated usingtumor size, tumor weight, mean survival time, body weight of tumor bearing mice and haematological parameters. Results found that oral administration of extract would significantly increase the life span and restored the altered haematological parameters. Tumorsize and tumor weight were also considerably reduced.