One of the group of natural products i.e. terpenoid mainly reported and found in all classes of living things. These terpenoids belongs to the group of secondary metabolites and these are naturally occurring hydrocarbons produced through a wide variety of plants, animals including microbes. Several terpenoids extracted from medicinal plant products and considered them as immunobiologically active molecules and used against various infectious diseases. Most of the bioactive terpenoids were identified with numbers of them having organ-protective effects while few are known for their nonbeneficial properties for humans. Since most of these terpenoid derivatives are reported in a very minute amount in nature but their massive harvesting in order to obtain higher amount of the drug applying various synthetic biological based techniques and metabolic engineering which mainly provides some innovative approaches pertaining to increase the production of terpenoids. In this review, we discuss about most common terpenoids reported from medicinal plant products and useful for human healthcare.