Hemidesmus indicus and its substitute Decalepis hamiltonii are an important and widely used medicinal plants belongs to family Apocynaceae and majorly contains phyto-constitutes such as hexatriacontane, lupeol, α-amyrin, β-amyrin, 2-Hydroxy-4-methoxybenzaldehyde (2H4MB) and sitosterol. The roots of the drug used as coolant and a blood-purifier in traditional system of medicines having properties like emetic, diuretic, anti-inflammatory, etc. Due to its over exploitation, limitations for natural regeneration the said drug is in the vulnerable in the forests. The roots of H. indicus (Sariva) in ayurvedic preparations like Amritamalaka taila, Drakshadi churna, Shatavari rasayana and Yeshtimadhu taila. Serious efforts for high quality studies is required to identify the novel clinical properties of the plant, the identification and isolation of the particular compound responsible for the specific activity.