According to the World Health Organization, more than 80 % of the world’s population totally relies on traditional forms of medicine, largely plant based to meet the primary health care needs of the people. In India, collection of medicinal plants from different regions, i.e. Western Ghats, Himalayan region etc. and processing these plant products like leaf, stem, and root and separates its primary as well as secondary metabolites and contributes a major part in Immunopharmacology especially for immunomodulatory activities. These immunomodulatory activities are so important for human beings pertaining to safe from various types of diseases. Currently, researchers more focused on medicinal plant products and considered as modulators of the complex immune system. Various studies were conducted and explored the metabolites chemicals in the form of saponins, flavonoids, terpenoids, glycoside, etc. These metabolites are mainly responsible to cause alterations or changes in the immunomodulatory properties. In this article, we collect some information about immunomodulatory activity of medicinal plant products. The major aim is too focused on plant based immunomodulators and capable for determining and modifying the immune response. Now a day, these immunomodulators may be required to speed up the process, development and maturation of specific and non-specific immunity in young susceptible animals, and also maintain immune surveillance.