Sapindus trifoliatus Linn. belongs to family Sapindaceae is commonly known as Reetha. It is a deciduous tree with medium-to-large in size, an some species exists as shrub too. This tree is an important forest tree species. Sapindus trifoliatus is commonly known as soapberries and soapnuts since the fruits are used to make soap and acting as natural detergent. Being a good source of saponins, Sapindus species have a significant role in economical value as well as in medicinal industry. It has been used by Unani physicians since antiquity as surfactant and for cleaning hair. Reetha is the ingredient of various herbal formulations and shampoos. It has valuable role in the treatment of lices and dandruff. Different pharmacological studies reported its potential as anti-epileptic, spermicidal, anti-inflammatory, anti-helmintic, anti-ulcer, anti-cancer, anti-diabetic, anti-migraine, antioxidant activity etc. This review summarizes the information described in classical Unani text and scientific research conducted on different parts of Sapindus trifoliatus plant.