Hepatic disease is a united term for an entire group of trouble that afflicts the tissues, structures and cells of the human liver. Large number of important functions is performed by liver, so there are lots of opening for somewhat to go incorrect. One of the most common causes of liver disease is inflammation, which often results from abuse of alcohol, poor diet or even malnutrition. Drug induced liver damage or liver dysfunction is the most important health crisis that challenges not only medical personnel but also the pharmaceutical field and drug control board. According to the United States Acute Liver Failure Study Group, drug induced liver injury accounts for more than 50% of acute liver failure, including hepatotoxicity caused by over dose of acetaminophen (39%) and idiosyncratic liver injury triggered by other drugs. The present paper deals with the hepatoprotective activity of some indigenous medicinal plants containing aqueous extract of AI: Abutilon indicum (Leaves), PN: Phyllanthus niruri (Fruits), EA: Eclipta alba (Leaves) and AS: Allium sativa (Bulb) against paracetamol induced liver toxicity in albino rats. The results indicate that aqueous extract showed significant hepatoprotective activity as compared to the hepatotoxic control at the dose of 200 mg/kg.