Background: Kalanchoe pinnnata and Pogostemon benghalensis are known to have many medicinal values. Both the plants are having many important phytochemicals. However, very few of these claims have been reported and scientifically studied. Methods: The leaves of the studied plants were extracted for the further experiments and water extraction was carried out using classical method. Qualitative tests were conducted to find the presence of the important photochemical. The determination of the anti-microbial property was done by the disk diffusion method against two pure cultures of Klebsiella pneumoniae and Staphylococcus aureus. Results: Qualitative analysis of the photochemical showed the presence of steroids, terpenoids, flavonoids and saponins in the leaves of Kalanchoe pinnata and the presence of steroids, flavonoids, glycosides, alkaloids and tannins in the leaves of Pogostemon benghalensis. The results found from the disk diffusion method clarifies that both the plants are having anti-microbial property. In Mueller Hinton Agar for Klebsiella pneumoniae the leaf extract of Pogostemon benghalensis (sample 1) showed a zone of inhibition was 9 mm (including diameter of disk is 6mm) and for Kalanchoe pinnata (sample 2) was 8 mm (including diameter of disk is 6mm). Similarly, the zone of inhibition for the culture of Staphyllococcus aureus of Pogostemon benghalensis (sample 1) was 8 mm (including diameter of disk is 6mm) and that for Kalanchoe pinnata (sample 2) was 9 mm (including diameter of disk is 6mm). Conclusion: The current study confirms many photochemical to be present in the studied plants. Also, their anti-bacterial properties were enumerated and thus support scientific basis for its use in traditional medicine.