The present research works were undertaken to study the diversity of CAM plants in major districts of the Malwa region. Based on a field study, a total of 62 species, belonging to 29 genera and 13 families were collected from the different locations of the study area and were described along with botanical names, common name, families and uses. Euphorbiaceae was reported as the dominant family. Other main contributing families were Agavaceae, Cactaceae and Crassulaceae. The field study was carried out from January 2014 to December 2018 in major districts of the Malwa region (M.P.) India.