Nigella Sativa, generally known as Kalonji, Black Cumin, Black Seed, Onion Seed, is a therapeutic spice. It not only gives additional flavor to the food but also has been observed to be effective in the therapy of many diseases. The study was conducted to find out therapeutic uses of Nigella Sativa. About 24 research papers were studied from various databases like Pubmed, Google Scholar, web of Science, Scopus, Science Direct etc. both national and global research papers were included. Most of the database included for consist of original research papers and systematic review papers. The results revealed that Nigella Sativa has a therapeutic effect on hyperlipidemia, have anti-inflammatory effect, is effective on lowering blood glucose levels, has anti-cancer properties, controls thyroid dysfunction, helps in weight management, and many more therapeutic benefits. It is thus concluded that Nigella Sativa can be used as a herbal remedy in many diseases thus not only being cost effective but also having no side effects. It can also be proposed as preventive strategy for many metabolic disorders. It is considered to be a very important spice in Unani medicine and is also named as “The Prophetic Spice” by some. Further, more exclusive and intensive randomized control trials need to be conducted on the effect of Nigella Sativa on hyperlipidemia, cancer, obesity, thyroid and even oral health