Background: As of 2015, an estimated 415 million people have diabetes worldwide, with type II DM making up about 90% of the cases. From 2012 to 2015, diabetes is estimated to have resulted in l.5 to 5.0 million deaths each year which makes it one of the 4 leading causes of death. The level of morbidity and mortality due to diabetes and its potential complication are enormous and pose significant healthcare burdens on both families and society. Madhumeha is one of the 20 Pramehas, which comes under Vataj subtypes and is charaaterized by the sweet urine resembling Honey. Madhumeha as considered as Asadhya‟ owing to its chronicity and its nature of effecting deeper tissues. Diabetes is a metabolic syndrome characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Aim and Objectives: to study the effect of khadir pooga vasti and khadir pooga patikashaya in Madhumeha and to observe the effect of khadir pooga vasti and khadir pooga vasti along with patikashaya on fasting blood sugar, post prandial blood sugar, urine sugar fasting and post prandial and glycosylated hemoglobin i e HBA1C. Methodology: In this study, 30 patients will be divided randomly into two groups (15 in each group). In Group a Khadira pooga vasti will be administered at morning time empty stomach. In Group B, Khadira pooga vasti (rectal enema) will be administered at morning time empty stomach, along with patikashaya of Khadira and pooga will be administer orally or 14 days. Results: We will observe the changes in subjective as well as objective parameters. Conclusion: Khadira, pooga vasti and patikashaya will be lowering the value of blood glucose.