Background: Traditional medicinal system like the TCM (Traditional Chinese Medicine) has successfully contribution against COVID-19. Now, the ancient science of Ayurveda is being looked upon. Ayurveda holds a treasure of valuable herbs that might help in this situation. Ashwagandha (Withaniasomnifera.Linn) is one such wonder herb. It holds a prominent place among Rasayana herbs of Ayurveda. Many systematic reviews of Ashwagandha considering its adaptogen, anti-cancer, cognition enhancer etc. activities are available. However, none could be found to exclusively review its anti-viral and immunomodulator activities. Aim: Hence, these two aspects were chosen especially bearing current COVID-19 situation in mind. Conclusion: The current systematic review study indicates that the use of Ashwagandha for immunomodulatory, anti-viral and especially against COVID-19 has a logical and scientific basis.