The role for vaccine adjuvants in case of veterinary and human vaccines has been a matter of great interest for the last so many years. Till now, only one adjuvant i.e. alum that are approved by Food and drug administration (FDA) for human use as well as for research purpose. Now a day, researchers worked with some plant based immunostimulators pertaining to determined humoral and cell mediated immune response against specific protein antigen. The only drawback for alum which enhanced only humoral response and poorly elicited cell mediated immunity. In an effort to search for those adjuvants that are derived from various medicinal plants and showed minimal side effects including toxicity. In this review, we focused on plant derived molecules or candidate used as adjuvant against specific protein antigen.