Nanomaterials may be considered as one of the most promising commodities especially in the field of healthcare, drug-gene delivery, environment, electronics, etc. One of the major investigation revealed applications of nanoparticles and its effect is totally varied with the phases, sizes, and morphologies of these particles. Thus, governed synthesis of nanomaterial with unfamiliar framework has gained much attention. With further improvement, nanoparticles synthesized from medicinal plant products and may provide potential and valuable end products with numerous applications in many fields providing a superior, ecofriendly alternative for harsh and toxic rules, practiced till date. Recently, nanotechnology was gaining more importance in the field of plant science, due to the need to develop miniaturized efficient systems pertaining to improve its seed germination including its growth and protect the plant due to abiotic and biotic stresses. Now a day, major challenge for researchers using plant products as a promising cure for various infectious diseases. In literature, more than 3000 medicinal plant species are reported and showed various immunopharmacological properties but these crude extracts are not proven to be specific and even the doses are not well-defined. Various efforts were taken by researchers to improve the therapeutic effect against infectious diseases from these natural compounds in the form of nanoparticles extracted from medicinal plants and showing some promising results for human healthcare.