This review provides updated Pharmacological activity of Jatropha gossypiifollia and senna alata. Jatropha gossypiifollia used as analgesics, neuropharmacological agents, anti-diarrheal, anit-cancer, hypotensive, vasorelaxant, coagulant and anti-inflammatory, anti-pyretic, anti-oxidant, anti-microbial, hepatoprotective, and anti-diabetic activity. Latex of J.Gossypiifollia used as hemostatic agent. The J.gossypiifollia leaves are used to treat multiple boils in the skin, dermatitis, itches, and tongue sore of babies, inflammation of milk secreting glands, stomach ache, and sexually transmitted diseases and also the leaf decoction is used for cleaning the wounds. Seeds are emetic and purgative. Senna alata roots, leaf, bark, flower and seed extracts possesses pharmacological activities such as anti-inflammatory, antitumor, antioxidant, analgesic, and antimicrobial, immune boosting activities.