Although, discovery of antibiotics, vaccination and development in medical science helped in remarkable reduction in infectious and communicable diseases, but the prevalence of non-communicable diseases (NCDs) including mental problems is increasing with alarming rate in the present era. Psychiatric disorders not only affect individual’s quality of life and apparent well-being, but also disturb other family members. One among them is melancholia (a type of multiple depressive disorders). Depressive disorders etiology is very complex and not well understood in allopathic medicine, so that the treatment is also not satisfactory. The drugs used in modern system for mental illnesses including melancholia also show adverse effects and prolonged use causes drug dependency. Therefore, there is need of new therapeutic options. In this context, Unani Medicine, an ancient world fame traditional medical system, can play an important role in reducing the burden of mental illnesses prevalent at global level. In this paper, an attempt has been made to discuss Melancholia/Depression from its concept to management in Unani perspective. Unani terms are used as well to illustrate the richness of Unani terminology. This review will help in better understanding about the depressive disorders, providing healthcare to mankind parallel to modern medicine as well as substitute to allopathic drugs.