Diabetes mellitus is very series health problem. Most of the death in the world due to diabetes. This may cause the many complications and affect the numerous organs in the body. The diabetes is the main problem of the hyperglycemia. The diabetes causes the extensive term impairment to the abnormal functioning and causes the nonfunctioning of the organ. The diabetes in rat the consumption of diminished the carbohydrate leads to the lipolysis resulted in hyperlipidemia. In spite of the presence of known medicines against the diabetic activity in the therapeutic market but these molecules can cause the certain tricky like medicinal impact. Newly some medicinally active plants have good antidiabetic activity. There are 400-450 different species having good antidiabetic phenomena. In this paper we used the leaves of plant Fimbristylistetragona for the antidiabetic activity. It has been showing the excellent antidiabetic activity. This activity was measured in terms of the alpha-Glycosidase inhibitory activity and it also shows the good in-vitro alpha-amylase inhibition. Both activities were performed in the inventor model. The aqueous extraction of leaves of plant Fimbristylistetragona has excellent activity.