Aim: Atalantia monophylla DC. Family-Rutaceae is one among the traditionally used medicinal plant being used by the local healers for its multiple therapeutic indications. Present review aims to collect all available ethnomedicinal information and research updates on A. monophylla. Material and Methods: Ethnomedicinal uses of A. monophylla were searched from available books related to medicinal plants and published research articles. Name of reporting tribe using the plant and their place of reporting, vernacular names, parts used along with the therapeutic uses with specific methods of administration were noted, along with various researches. Results: A. monophylla has been reported for its traditional therapeutic uses in 3 countries across the globe and in 8 states of India. Various parts of the plants like leaf, root, root bark, stem, stem bark, fruit, berry and seed alone or along with other drugs are used in the management of 55 diseases conditions either through external applications or internal administration. Among these, maximum is indicated in the treatment of rheumatism, paralysis, cough, arthritis etc. Its leaf has maximum application in 33 disease conditions, followed by fruit in 28, root in 16, berry in 13, seed in 10, stem bark in 9, root bark in 3 and stem in 2 diseases condition. Its leaves are also used as pickle, engraving and cabinet-work. Pharmacological studies report its anti-inflammatory, immuno-modulatory, antioxidant activities, etc. Conclusion: A. monophylla is a promising drug having multifaceted ethnomedicinal uses. Its use in rheumatism, paralysis, cough, arthritis etc. should be scientifically evaluated through pharmacological and clinical studies to establish the ethnic claims.