Aim and objective: Punica granatum Linn., family Lytheraceae, one of the m post common domesticated plant and also traditionally used by local traditional healers for various disease conditions. The present review aims to collect all available ethnomedicinal information and research updates on the plant. Material and methods: The documented ethnomedicinal uses of P. granatum from 20 books on medicinal plants and 86 research articles on ethnomedicine published until December 2020 were reviewed. Name and place of the reporting tribe, parts used along with their therapeutic indications were noted by either external (E) or internal (I) with a particular method of administration if available. Results and discussion: Punica granatum is being reported for its therapeutic uses in 14 states of India and other 10 countries across the globe. Its fruits, fruit rind, leaf, stem bark, seed, flower, stem, root, root bark, twig and whole plant are used in 41 different disease conditions, either through internal administration or external applications in the treatment of diarrhoea, worm infestation, dysentery etc. through various pharmacological and clinical studies. Antidiarrheal, anthelmintic, antihypertensive, nephron protective, hepatoprotective, estrogenic, uterine contraction etc. activity has been reported. Conclusion: Punica granatum is having multi-layered ethnomedicinal uses. Some of the ethnomedicinal claims are not validated yet. Its use in vomiting, piles, rectal prolapse, conjunctivitis / cataract, leucorrhoea, epistaxis, migraine, fever and anaemia should be evaluated through pharmacological and clinical studies to establish the ethnic claims.