Aloe castellorum and Aloe pseudorubroviolacea of the genus Aloe belong to the family Asphodelaceae was found to be highly endangered in the Arabian Peninsula. It has rich medicinal properties and also very important to human health. It was found to be threatened species also remain only at very few localities and highly endangered in the Arabian Peninsula. Described here morphology character and antibacterial activity. The two plant extracts having significant antibacterial activity, meanwhile the methanolic extract of Aloe castellorum and Aloe pseudorubroviolacea shows higher antibacterial activity than other extracts.