Novel corona virus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) characterized by acute respiratory illness potentially destabilize the health and wellness of the population around the globe. In search of several therapeutic preparations in management of COVID-19, herbs offer considerable better remedy as hypothesized by several research outcomes. Nochi kudineer is one such novel preparation of kudineer indexed in classic Siddha formularies indicated to counteract the infection and to enhance the immune makeup. The main aim of the present investigation is to evaluate the anti-viral potential of the phytotherapeutics such as Friedelin, β-pinen, Vitexin, Piperidine, Piperine, Ajoene, Allicin, Hydroxychavicol and Eugenol present in the formulation Nochi kudineer against the enzyme target 3-chymotrypsin-like protease (3CLpro)by using Auto Dock prediction. Results of molecular docking analysis strongly suggested that out of nine phyto components leads such as Friedelin, Vitexin, Piperine, Ajoene and Allicin posse’s maximum of 5 interactions with the core active amino acid residues present on the target. It was concluded from the results of the present investigation that phytochemicals present in the formulation Nochi kudineer reveals significant 3-CLpro enzyme inhibition property. Hence upon further clinical validation preparations like Nochi kudineer may be considered as a drug of choice for the management of COVID-19 in the near future.