The present study documented the medicinal weeds from Palasdhari, Maharashtra. A total of 90 species of weeds belonging to 81 genera of 41 families were recorded during the study. Majority of the plants studied were permanent weeds of the study area. Maximum number of weeds were represented from the family Compositae. Botanical name, common name, family, medicinal uses and pharmacological activities and the phytochemical constituents were reported. The study was an attempt to create awareness among the public of the medicinal treasure of the area. With proper plans and community participation, Palasdhary could be developed not only as a promising economic and bioresource centre for medicinal drugs but also conservation of the rare medicinal weeds.