Controlling weeds with herbicide is the most efficient way due to its advantages, compared with other control measures. Weeds must be controlled as they will compete with rice plants and become the host for pests and diseases, which can reduce the rice yields by 87%. The objective of this research is to investigate effectiveness of pyrazosulfuron-ethyl 10% herbicide in controlling grass and broad-leaved weeds on rice paddy cultivation. It was conducted in Gegesik Village, Arjawinangun Sub-district, Cirebon Regency, West Java. It used group random design with single factor, nine treatments, and four repetitions. The treatments consisted of seven treatments with nine dosages of pyrazosulfuron-ethyl 10% herbicide i.e. dosages of 0.60 kg ha-1, 0.75 kg ha-1, 1.00 kg/ha-1, 1.25 kg ha-1, 1.50 kg ha-1, 1.75 kg ha-1, 2.0 kg ha-1; manual weeding; and no weeding as control group. Pyrazosulfuron-ethyl 10% herbicide is effective in controlling the dominant weeds and the co-dominant weeds on rice paddy plants such grass weeds as species of Echinocloa, Colona, and Leptochloa chinensis and such broad-leaved weed classes as Monochoria vaginalis and Spigelia Anthermia up to 12 weeks after application (WAA12) observations with the doses of 0.75 kg ha-1-2.00 kg ha-1. At the doses of 0.60 kg ha-1- 2.00 kg ha-1 up to WAA3, no symptoms of poisoning in rice paddy plants were observed. Pyrazosulfuron-ethyl 10% herbicide at the dose of 1.75 kg ha-1 shows that the height of plant was 55.08 cm while at the dose ranges of 0.6 kg ha-1- 2.0 kg ha-1, it shows that the average milled dry grain weight ranged from 8.20 to 9.97 kg plot-1sample.