Snake venoms are complex mixtures of numerous proteins and peptides and extensive interspecific variation in venom composition. Enzymes existing in snake venom hydrolyze protein which leads to tissue gangrene and blood coagulation. Phosphodiesterase A2 causes hemolysis by lysing cell membrane of red blood cells (RBCs). In the present study examined anti-hemolytic activity of aqueous leaves extract of Salvia leucantha against Indian cobra (Naja naja) crude venom. The aqueous leaves extract of S.leucantha was found to have phenomenal anti-hemolytic potential against the crude venom as probed by in vitro assay. A rapid inspection of the figure suggests that 200μg/ml of the extract could inhibited about 49% and 800μg/ml of the extract was inhibited the 87% of hemolytic activity of the cobra crude venom. In indirect haemolysis about 12μg of cobra venom produces 14.02mm of haloes. Various concentrations of plant extract were pre-incubated with venom inoculated on the egg yolk agarose gel plate and notably 200μg/ml of extract produces 7.02mm halos, it was calculated inhibition was 50%. The maximum concentration of plant extract 800μg/ml inhibited the 84.80% of indirect haemolysis (PLA2) on egg yolk agarose gel plate. This was concluded that aqueous leaves extraction of Salvia leucantha have the ability to inhibiting direct haemolysis and Phospholipase A2dependant hemolysis.