Amavata is one of the commonly affected lifestyle and degenerative disorder. It is equated with Rheumatoid Arthritis, an inflammatory autoimmune disorder. The major aim of treatment of this disease is to provide relief in the form of reduced pain and discomfort, prevention of further disease process, loss of joint function, maintenance of productive and active life and above all to restore the vitality of the body (oja) or a good immune status. The present study was aimed to assess the effect of Ajmodadi vatak in the management of Ama vata with special reference to Rheumatoid Arthritis. Total 40 randomly selected patients of Amavata were registered among them Group I, 20 patients on Ajmodadi vatak was given to these patients and Group 2; 20 as control group celecoxib was given for one month. On the basis of observations and the results of this present study it can be concluded that effect of the trial drug i.e., Ajmodadi vatak along with and Virechana are effective in majority of the symptoms.