Nowadays Amavata is a very common dreadful disease. Amavata has been named keeping view two predominant pathological factors viz. Ama and Vata. When Ama and Vata simultaneously get vitiated and enters the Trika and Sandhi finally leading to stabdhata (stiffness) of the body, the condition is known as Amavata. This study is designed to evaluate the efficacy of Ajmodadi vatkam followed by virechana over Amavata. A total of 40 randomly selected patients of Amavata were registered among them Group 1; 20 patients on Ajmodadi vatak and virechana was given to these patients and Group 2; 20 as control group celecoxib was given for one month. Statistically, significant improvement was found in curing amavata symptoms and also highly significant results were found in symptoms of Amavata.