Skin is affected by oxidative stress due to the formation of reactive oxygen species, which trigger the development of sunburn, erythema, edema, photoaging, skin cancer, etc. Protection of skin from photodamage is an urgent concern. The use of sunscreen is the most common practice nowadays that protects from the adverse effect of UV radiation. In the present study, sunscreen is formulated using melatonin and curcumin which was further evaluated by measuring organoleptic characters, moisture content, % drug release, spreadability, antioxidant potential, and FTIR study, etc. Results showed that formulations have shown good consistency with no degradation of herbal actives while formulating it and shown good spreadability. FTIR study showed that the same functional groups were present in both drug and formulation. So it was confirmed that curcumin and melatonin were incorporated in the cream formulation. From the study, It can be concluded that melatonin, curcumin, and zinc oxide containing formulation can be a new sunscreen therapy with anti-aging property.