Aquatic macrophytes are well known accumulators for heavy metals in contaminated water bodies. The present study aims at developing a protocol for decontamination of waste water containing sewage using a biological treatment system by employing a selected floating macrophyte - Azolla pinnata, occurring in the native aquatic ecosystems. The pond receiving sewage as well as the laboratory wastes from the Centurion University of Technology and Management (CUTM) campus located at Bhubaneswar belonging to Khurda district of Odisha was selected as the sampling site. High magnitude of suspended solids, BOD, nitrogen and phosphorus in the sewage of CUTM campus indicated the high pollution load. The BOD and total suspended solid values ranged from 302- 389mg/l and 419-511mg/l respectively. Sewage at different concentrations increased the fresh weight of Azolla by 1.5-3.6 times over those grown in tap water. The nitrogen contribution of Azolla pinnata R.Br. in different treatments followed almost a similar trend as that of the fresh matter yield. Besides, culture of Azolla pinnata R.Br. for fifteen days resulted in reduction in the total suspended solid, BOD, nitrogen and phosphate content of the effluent to minimum accepted standard value. These responses indicate the potential of Azolla pinnata not only as a water pollutant scavenger but also a suitable tool for phytoremediation in the aquatic environment.