Doronicum hookeri Hook.f. Commonly known as Leopard’s bane is the root of a perennial herb mostly distributed in Sikkim Himalayas between 12000- 14000 ft, Syria, Africa, Iran, Europe and Spain. It is also known by various other names like Darunah, Darunak, Aqeer, Tus, Tarang, Qarufas, Qarunas etc around the globe. It belongs to the family Asteraceae and has been used in the treatment of various ailments and conditions like palpitation, scorpion bite, plague, nightmare, indigestion, pain abdomen, chest pain, headache, flatulence, cough, fatigue, paralysis, palsy, inflammation, labour pain, renal and bladder stone. Beside these, it has other pharmacological activities like neuro, liver and spleen tonic, stomachic, exhilarant, foeto-protective, aromatic and alexiteric. It contains alkaloids, flavonoids, triterpenes, saponins, coumarins, essential oils and cardiac glycosides. This review paper exclusively presents the morphological and microscopic structure, temperament, chemical constituents, pharmacological actions, uses in diseases, dose, important formulations and adverse effects of Doronicum hookeri with the reference of not only ethnobotanical data and pharmacological studies but also with the reference of Unani literature in detail and gives a new impetus to utilize this drug in various disorders. Number of in vivo and in vitro studies have also reported its antibacterial, antifungal, antioxidant and hepatoprotective activities.