The medicinal plants are generally used by the traditional medical physicians for therapeutic use of various ailments in their daily practice. Ocimum sanctum Linn., which belongs to the family Lamiaceae also known as Tulsi in Hindi, have been mentioned in Unani medicine for the treatment of Iltehab Shobatur Riyah (Bronchitis), Zeequn Nafs (Bronchial asthma), Ishal (diarrheoa), Zaheer (dysentery), Wajaul mufasil (arthritis), Humma (chronic fever) etc. It has also been recommended to retain antifertility, anticancer, antimicrobial, hepatoprotective, cardioprotective, antiemetic, antispasmodic, antiemetic, analgesic, antidiabetic, antifungal, adaptogenic and diaphoretic activities. In this review, an effort has been made to assemble the pharmacological actions, therapeutic uses and pharmacological activities of Ocimum sanctum Linn. In classical text.