The ethanolic extract of Erythrina variegata was screened for phytochemical analysis and in vitro antioxidant activity. The antioxidant activity screened through DPPH, total antioxidant assay, super oxide metal chelating, iron reducing power activity and nitric oxide scavenging activity at different concentrations and ascorbic acid as a standard antioxidant. Bioflavonoid content of Erythrina variegata attributed the concentration dependent antioxidant activity. Overall antioxidant activity of Erythrina variegata was found to be the strongest. The present study reveals that the Erythrina variegata would exert several beneficial effects of virtue of their antioxidant activity and could be rendering useful as drug formulation.