Nardostachys jatamansi from the major natural resources base of the Indian indigenous health care tradition, the medicinal value of drug plant is due to the presence of some chemical substances in the plant tissues which produce a definite physiological action on living biological body. Jatamansi plants synthesize hundreds of chemical compounds for functions including defense against insects, fungi, diseases, and herbivorous mammals. Due to the global popularity of Ayurveda, there is a constant increase in demand for herbal drugs in the last few decades thus exerting huge pressure on natural resources. According to modern science, drugs possess highest potential during its collection period. The climate temperature, soil conditions, rainfall, duration of daylight, altitude, methods of cultivation, collection from the wild area, effect of lunar cycle, and methods of collection, processing, and storage have an impact on the secondary metabolites of the plant ultimately which affect the therapeutic efficiency of the drug.