The present study aim to record locally available plants of ethno-medicinal importance used by the tribal people of the villages of Sohra (Cherrapunjee) and Mawsynram, two places located in the East Khasi Hills District of Meghalaya that currently hold the 1st and 2nd place in the list of Wettest places on Earth. A total of 110 plant species belonging to 92 genera and 56 families were found to be used traditionally in curing various ailments and diseases as per data collected in these two villages. Of these 110 plant species, the dominant family with maximum number of species being used in traditional medicines was documented to be Asterceae with 8 number of species followed by Rutaceae (7 number of species), Liliaceae (6 number of species), Fabaceae (5 number of species) etc. Plant parts more frequently used are leaves followed by fruits, whole plant, roots, tubers, seeds, flowers etc.