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VOL. 6, ISSUE 2 (2021)
Pharmacognostical and pharmaceutical analysis of pramehahar guggulu–An ayurvedic polyherbal formulation for clinical trial of diabetic nephropathy
Authors
Kanchan Bala, Alankruta R Dave, Harisha CR, VJ Shukla
Abstract
Background: Diabetic nephropathy is a disorder affecting the kidneys, in the form of damage to the glomerular basement membrane, mesangial cell proliferation and glomerulosclerosis. The kidney involvement is heralded by persistent albuminuria (>300 mg/24 hr or 200μg /min) and is the hallmark of diabetic nephropathy. Diabetic Nephropathy is not directly mentioned with a name in the Ayurvedic classical text books. Because of main characteristic features of albuminuria with hyperlipidemia, it may be included under the title of prameha (a disease of urinary system with altered composition, frequency and quantity of urine). Albuminuria makes urine concentrated, viscid or dense. These features can be correlated with sāndrameha a subtype of prameha. Aim: To analyze the Pharmacognostical and Pharmaceutical properties of Pramehahar Guggulu. Materials and Methods: Pramehahar Guggulu was subjected to microscopic evaluation for pharmacognostical study, physico-chemical analysis like hardness, weight variation, loss on drying, ash value, acid insoluble extract, pH value, water soluble extract,alcohol soluble extract and high performance thin layer chromatography (HPTLC). Result: Pharmacognostical study showed the presence of certain identifying characteristics of all the ingredients of Pramehahar Guggulu that is Punarnva, Guggulu, Haridra, Shirish, Varun, Shigru, Guduchi, Amalki, Usheer and Dhanyak. In pharmaceutical study, preliminary physico-chemical analysis showed that hardness of Pramehahar Guggulu was 6.8kg/cm2,ash value 10.39%w/w, loss on drying 10.17% w/w,water soluble extract 32.6% w/w, alcohol soluble extract 19.2% w/w and pH value 6.5. HPTLC analysis showed eleven spots in 254 nm and nine spots in 365nm. Conclusion-Present work was carried out to standardize the polyherbal formulation Pramehahar Guggulu in terms of its identity, quality and purity. Pharmacognostical and physico-chemical observations revealed the specific characters of all the active constituents in the preparation.
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Pages:573-576
How to cite this article:
Kanchan Bala, Alankruta R Dave, Harisha CR, VJ Shukla "Pharmacognostical and pharmaceutical analysis of pramehahar guggulu–An ayurvedic polyherbal formulation for clinical trial of diabetic nephropathy ". International Journal of Botany Studies, Vol 6, Issue 2, 2021, Pages 573-576
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