Medicinal plants have bioactive compounds which are used to curing of various diseases. In this present investigation involves six plants of genus Cucumis L. and Momordica L. were studied for different solvents Viz. Acetone, methanol, petroleum ether, chloroform were used to obtain extracts from produced plant fruits. The extracts were subjected to qualitative phytochemical screening using standard procedure. Phytochemical screening reveals the presences of Alkaloids, Saponins, Tannins, Steroids, Glycosides and Flavonoids etc.